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Accardo Lab

Light-assisted manufacturing of Multi-scale 3D cellular microenvironments

 
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Research

Using light to structure biomaterials for cell culture applications

We develop versatile multi-scale (nano-micro-meso) fabrication paradigms to address a range of open questions in cell biology.


We are interested in the design and fabrication of 3D architectures by employing light-assisted additive manufacturing techniques (such as two-photon lithography and stereolithography).

We plan to exploit these 3D engineered microenvironments for studying the mechanobiology, migration and differentiation mechanisms of cells as well as of spheroids/organoids.

We dream to use these platforms for prospective applications in the field of in-vitro 3D models (e.g. for neurodegenerative diseases, cancer) and tissue engineering (e.g. for neural or bone scaffolds).

 

News

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June 1, 2019

I officially joined TU Delft within the Department of Precision and Microsystems Engineering (PME) as Tenure-Track Assistant Professor of Soft Micro- and Nanosystem Technology for Life Sciences and Biology!

Excited to start this challenging adventure and set up my new lab!

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September 9, 2019

Beatriz Costa, visiting Master Student from University of Minho (Portugal), is the first member of my team!
She will work on 3D fabrication and mechanical characterization of polymeric/hydrogel scaffolds.

Welcome Beatriz!

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September 16, 2019

Keynote Lecture entitled "To scaffold or not to scaffold: pros and cons in the realization of biomimetic neuronal microenvironments" at the Symposium "Bioinspired and Biointegrated Materials as New Frontiers Nanomaterial" that I am honored to chair during the  2019   E-MRS Fall Meeting in Warsaw.

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October 7, 2019

Excited to have joined the Brain-on-chip group, part of the human Organ and Disease Model Technologies (hDMT) consortium.

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November 14, 2019

The Special Issue "3D Microfabrication Unleashed: Emerging Applications and New Manufacturing Concepts" in Micromachines Journal is open for submissions!

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December 10, 2019

Giving a talk in Utrecht on "Multi-scale engineered cell microenvironments by laser-assisted additive manufacturing" at the International MicroNanoConference 2019.

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December 13, 2019

The first paper of my professorship at TU Delft is out: "Engineered 3D Polymer and Hydrogel Microenvironments for Cell Culture Applications". (Open Access Review article) 

Also, the first PhD position in my group on "Light-assisted 3D manufacturing of neuronal microenvironments" is now open for applications. (Deadline 15/1/2020)

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December 20, 2019

Dian Veldkamp, PME Master Student, joined our team!

She will develop a graduation project on 3D fabrication and 3D imaging of engineered micro-environments for guiding the fate of neural stem cells.

Welcome Dian!

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January 23, 2020

I am very honored to be the recipient of the 1st Place grant of the TU Delft Health Initiative Pilot Projects call. Within this project, involving a strong synergy between TU Delft and the Holland Proton Therapy Center, we will start to explore the development of 3D Onco-Scaffolds as a benchmark tool for Proton Radiobiology.

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February 10, 2020

Excited and honored to have been awarded a Cohesion Grant of 200 k€ from Sectorplan funding, together with Dr. Mohammad J. Mirzaali! This project will allow us to develop novel nanostructured 3D scaffolds by combining advanced mechanical engineering designs and light-assisted 3D micro-manufacturing. The beginning of a promising "cohesion" between the Department of Precision and Microsystems Engineering (PME) and the Department of BioMechanical Engineering (BME) at TU Delft.

Please have a look at the available PhD position.

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February 14, 2020

First oral presentation of our Visiting MSc Student Beatriz Costa at the hDMT (human Organ and Disease Model Technologies) international meeting! Good job Beatriz!

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March 24, 2020

Brian Roos, PME Master Student, joined our team!

He will develop a graduation project on 3D microglia-on-chip in collaboration with the Biomedical Primate Research Center (BPRC).

Welcome Brian!

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April 1, 2020

Welcome Ahmed Sharaf, freshly appointed PhD student in my group!

His project will be focused on Light-assisted 3D manufacturing of neuronal microenvironments.

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May 29, 2020

Congratulations to Saleh Aghajani, PME-MNE section PhD student that I am co-supervising, for his first author's paper entitled "Aerosol Direct Writing and Thermal Tuning of Copper Nanoparticle Patterns as Surface-Enhanced Raman Scattering Sensors" just appeared in ACS Applied Nano Materials!

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July 27, 2020

Qais Akolawala, PME Master Student, joined our team!

He will develop a graduation project on 3D microenvironments for glioblastoma proton radiobiology studies in collaboration with LUMC and the HollandPTC.

Welcome Qais!

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August 26, 2020

Excited to chair with Dr. Paul Wieringa a symposium on "Strategies for the realization of biomimetic neuronal microenvironments" at the 6th World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS2021) taking place in Maastricht next year!

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September 18, 2020

The chapter Nanoscaffolds for Neural Regenerative Medicine, part of the book Neural Regenerative Nanomedicine has been published! A nice collaboration with expert colleagues in the field!

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October 8, 2020

Nastaran Barin, PME Master Student, joined our team!

She will develop a graduation project on 3D engineered tumoral microenvironments for the study of primary and patient-derived glioblastoma cells in collaboration with ErasmusMC.

Welcome Nastaran!

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November 1, 2020

Welcome Ebrahim Yarali, freshly appointed PhD student in my group in collaboration with the Department of Biomechanical Engineering!

His project will be focused on the development of novel nanostructured bio-mimetic meta-implants for bone tissue replacement.

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May 6, 2021

Congrats Saleh Aghajani for his latest work on additive manufacturing of Au nanoparticle patterns featuring tunable photoluminescence and SERS behaviour.

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June 14, 2021

New collaborative paper with Mohammad Mirzaali on Curvature Induced by Deflection in Thick Meta-Plates just appeared in Advanced Materials!

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August 15, 2021

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August 27, 2021

Congratulations to our freshly graduated (9/10) MSc student Qais Akolawala!

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September 3, 2021

Thomas Michalica, PME Master Student, joined our team!
He will develop a graduation project on 2.5D Hybrid polymer/metal Neuron-On-Chip architectures by two-photon polymerization and multi-focal lithography in collaboration with Max Mastrangeli (EWI) and Jean Philippe Frimat (LUMC).

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September 20, 2021

Chihao Kuo, PME Master Student, joined our team!
He will develop a graduation project on hybrid soft/stiff polymer-hydrogel scaffolds in collaboration with Eduardo Mendes (TNW).

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September 28, 2021

Updated group picture on a very sunny day at TU Delft!

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October 10, 2021

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October 26, 2021

The Italian regional television channel Canale 10 interviewed me for talking about my 3D microenvironment research at TU Delft

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October 28, 2021

Congratulations to our freshly graduated (9/10) MSc student Nastaran Barin!

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November 1, 2021

Welcome back to Qais Akolawala who joined the team as Junior Researcher!

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November 11, 2021

Congratulations to our freshly graduated (7.5/10) MSc student Brian Roos!

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November 12, 2021

MNE Group picture at the Remastered museum in Rotterdam during our winter outing!

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November 17, 2021

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December 1, 2021

Welcome back to Nastaran Barin who joined the team as Visiting Researcher from ErasmusMC!

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December 1, 2021

Welcome back to Pieter van Altena who joined the team as PhD student working on 3D cell-instructive engineered stem cell models for neuropsychiatric disorders!